Desiderio Arnaz II was the youngest mayor of Santiago de Cuba (1923–1932). He was elected to the Cuban House of Representatives in November 1932 for the Oriente Province. When Gerardo Machado was overthrown as president in August 1933, Rep. Arnaz was arrested and jailed. Six months later, he was allowed to go into exile. He graduated from the Southern College of Pharmacy (merged and known now as Mercer University, School of College of Pharmacy and Health Sciences) in 1913 in Atlanta, Georgia. Rep. Arnaz was the son of Desiderio Alberto Arnaz y de Acha I (1857–1929), a doctor (and grandson of Manuel Arnaz, a mayor of Santiago de Cuba in 1869) and Rosa Alberni y Portuondo (1870-?), the great-granddaughter of a mayor of Santiago de Cuba, José Joaquín Portuondo y Rizo, 1st Conde de Santa Inés (1762–1824).