How deadly was the Black Death?

 In total, the plague reduced the world population from an estimated 450 million down to 350–375 million in the 14th century. . . . According to medieval historian Philip Daileader in 2007:

The trend of recent research is pointing to a figure more like 45–50% of the European population dying during a four-year period. There is a fair amount of geographic variation. In Mediterranean Europe, areas such as Italy, the south of France and Spain, where plague ran for about four years consecutively, it was probably closer to 75–80% of the population.

(according to Wikipedia)

Can you imagine 3 out of every 4 people in the United States dying from a disease?!